However, elevated levels of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1), B7-H3, and B7-H4 on CD8+ tumor-infiltrating lymphocytes (TILs) have been shown in NSCLC [3]. This evidence concerns the gene CTLA4 and neoplasm.