Interestingly, PD-L1 negative, nonsquamous NSCLC did not show a significant benefit of immunotherapy over chemotherapy that was seen in the squamous population (<1% PD-L1 OS HR is 0.9 [95% CI 0.66–1.24], <5% PD-L1 OS HR is 1.01 [95% CI 0.76–1.33], and <10% PD-L1 OS HR is 1.00 [95% CI 0.76–1.31]). Here, CD274 is linked to non-small cell lung carcinoma.