In randomized controlled trials evaluating various doses of IFNα in the adjuvant treatment of high-risk melanoma (stages IIB, III, or IV), a durable impact on both relapse-free survival (RFS) and overall survival (OS) was only seen with the regimen utilizing HDI as tested in Eastern Cooperative Oncology Group (ECOG) and US Intergroup trials E1684 (n = 287; significant RFS and OS benefit vs. observation), E1690 (n = 642; only RFS benefit seen vs. observation), and E1694 (n = 880; significant RFS and OS benefit vs. vaccine) [17–19]. Here, IFNA1 is linked to melanoma.