Based on safety data and further studies (including CheckMate 037), nivolumab is given at a dose of 3 mg/kg every 2 weeks in subsequent trials and became the second monoclonal antibody against PD-1 receptor to be approved by the FDA for the treatment of patients with unresectable or metastatic melanoma and disease progression following ipilimumab and a BRAF inhibitor (if BRAF V600 mutation positive). Here, BRAF is linked to metastatic melanoma.