Second, HL is characterized by genetic alterations in 9p24.1, which results in PD-L1 and PD-L2 copy gain and overexpression, with as many as 97% of newly diagnosed classical HL biopsy specimens demonstrating 9p24.1 copy gain or amplification [64, 65]. The gene discussed is PDCD1LG2; the disease is Hodgkins lymphoma.