Because of its efficacy in the treatment of relapsed/refractory Hodgkin lymphoma (HL) (either after autologous stem cell transplant or in patients who are not transplant candidates) and in relapsed systemic anaplastic large cell lymphoma, which are both malignancies in which CD30 is highly expressed, brentuximab received FDA approval for the treatment of both of these diseases in 2011 [30, 31]. The gene discussed is TNFRSF8; the disease is Hodgkins lymphoma.