NOS3 and endothelial dysfunction: The importance of eNOS in controlling vasodilation and blood pressure is highlighted by the vessel-constrictive effects of competitive eNOS inhibitors such as NG-monomethyl-L-arginine (L-NMMA) and NG-nitro-L-arginine-methyl ester (L-NAME) on endothelium-induced vasodilation in ex vivo experiments [103], and the clinical use of these inhibitors in the diagnosis of endothelial dysfunction [104].