CRP and acute kidney injury: In univariate analyses, metformin use (B = 0.39 mmol/L; P < .001), AKI (stage 1: B = 0.49 mmol/L; stage 2: B = 0.89 mmol/L: stage 3: B = 0.94 mmol/L; P < .001), male gender (B = 0.19 mmol/L; P = .001), Type 2 diabetes (B = 0.42 mmol/L; P < .001) and CRP (B = 0.001 mmol/L; P < .001) were associated with higher lactate concentrations (Table 4).