These hub genes were separately guanine monophosphate synthase (GMPS), acetyl-CoA carboxylase alpha (ACACA), albumin (ALB), transforming growth factor beta 1 (TGFB1), KRAS proto-oncogene, GTPase (KRAS), erb-b2 receptor tyrosine kinase 2 (ERBB2), BCL2, apoptosis regulator (BCL2), epidermal growth factor receptor (EGFR), and signal transducer and activator of transcription 3 (STAT3) and CD8a molecule (CD8A), which might play a critical role in HCC progression. This evidence concerns the gene ACACA and hepatocellular carcinoma.