Based on their morphology observed using electron microscopy and low molecular weight keratin (LMWK)-CAM5.2 immunohistochemical staining, corticotroph adenomas are divided into densely (DG-ACTH) and sparsely (SG-ACTH) granulated that correspond to subtype I and subtype II silent corticotroph adenomas, respectively [10] (Fig. 1a, b). The gene discussed is POMC; the disease is ACTH-producing pituitary gland adenoma.