In a recent report, it was also shown that siRNAs targeting Ror1 in CLL induced apoptosis and a small molecule inhibitor, Ror1 tyrosine kinase inhibitor dephosphorylated Ror1, down-regulating the activated PI3K/AKT/mTOR signaling pathway and inducing specific apoptosis of CLL cells66. Here, AKT1 is linked to B-cell chronic lymphocytic leukemia.