HMGA2 and hereditary leiomyomatosis and renal cell cancer: It is conceivable that all three leiomyoma subtypes may differ also in view of clinical characters, as it is already established that HLRCC-related FH-deficient tumours often show atypical histological features, develop at an earlier age, and are more numerous7, while HMGA2–aberrant tumours tend to be larger than other leiomyomas40.