It is conceivable that all three leiomyoma subtypes may differ also in view of clinical characters, as it is already established that HLRCC-related FH-deficient tumours often show atypical histological features, develop at an earlier age, and are more numerous7, while HMGA2–aberrant tumours tend to be larger than other leiomyomas40. Here, FH is linked to leiomyoma.