Growth differentiation factor 15 (GDF15), also known as macrophage inhibitory cytokine -1 (MIC-1) and non-steroidal anti-inflammatory drug activated gene-1 (NAG-1), is a divergent member of the transforming growth factor beta family, associated with immunosuppression, anti-apoptosis and anti-inflammation, growth inhibition and cancer cell invasion8. This evidence concerns the gene GDF15 and cancer.