Beside KDM1, KDM4A and KDM5A/5B are up-regulated in TMZ-resistant GB cells [12], KDM4B is up-regulated in response to irradiation [27, 28] and KDM6B was identified as a possible therapeutic target in the childhood Diffuse Intrinsic Pontine Glioma (DIPG) [17]. The gene discussed is KDM6B; the disease is diffuse intrinsic pontine glioma.