From a mechanistic point of view, we have shown that JIB 04 demethylates H3K4 and activates the expression of cancer-inhibiting genes, interferes with the PI3K/AKT pathway, one of the central survival mechanisms of cancer cells and that 60-minutes treatments are sufficient to activate death mechanisms and to drastically reduce or abolish the clonogenic properties of GB cells. The gene discussed is AKT1; the disease is cancer.