For example, it was demonstrated detailedly that miR-10b could regulate transcription factor TBX5 in breast cancer [31], E-cadherin in laryngeal carcinoma [33], HOXD10 in GC [34] etc. MiR-509-3-5P, less discussed nowadays, could lead to anti-proliferative effect in human lung cancer A549 cells by targeting PLK1 [28]. The gene discussed is TBX5; the disease is lung carcinoma.