CR1 and metastatic malignant neoplasm in the lymph nodes: We further investigated the relationship of CR-1 expression with the clinico-pathological features and found that CR-1 expression was significantly associated with depth of invasion (p = 0.002), TNM stage (p = 0.001) and lymph node metastasis (p = 0.044, Fig. 4D), suggesting high invasive/metastatic capacity of CR-1high cell subpopulation.