Multivariate Cox-regression analysis showed that only the depth of tumor invasion (HR = 1.465, 95% CI = 1.655–6.395, p = 0.018) and the expression of CR-1 (HR = 3.253, 95% CI = 1.066–1.2.011, p = 0.001) were independent prognostic indictors in ESCC patients (Table 2). Here, CR1 is linked to esophageal squamous cell carcinoma.