By multivariate analysis adjusted for the effects of all significant variables associated with survival in univariate mode, age (HR1.017 95% CI 1.000–1.035, p = 0.046), tumor stage (HR 1.577, 95% CI 1.189–2.091, p = 0.002), residual tumor (HR 2.337, 95% CI 1.518–3.597 p < 0.001) and CRP/Alb (HR 1.330, 95% CI 1.131–1.564, p = 0.001) remained significant independent predictors of OS (see Table 3). The gene discussed is CRP; the disease is neoplasm.