Concentrations of urine S100A8/A9 as well as the parameters of diagnostic accuracy (AUROC, sensitivity, and specificity) and the optimum cut-offs for the separation of dogs diagnosed with TCC/PCA from the other groups of dogs were comparable to those in one study evaluating urine S100A8/A9 concentrations in humans with bladder cancer [30]. This evidence concerns the gene S100A8 and tarsal-carpal coalition syndrome.