IGHE and chronic obstructive pulmonary disease: Recently, Cosio et al. reported an ACOS prevalence of 15% in a COPD Spanish cohort of over 800 patients using one major criterion for asthma definition (reversibility >400 mL and 15% plus medical history of asthma) or two minor criteria (blood eosinophils >5%, IgE >100 IU/mL, or two separate bronchodilator tests >200 mL and 12%) [22].