The kinase activity of the Beclin1-Vps34 complex is negatively regulated by Bcl-2 family proteins, which bind to Beclin1 and disrupt the interaction between Beclin1 and Vps34, leading to Beclin1 homodimer formation and inhibiting autophagosome formation [13] The role of autophagy in cancer is often reported as confusing and controversial. This evidence concerns the gene PIK3C3 and cancer.