A recent retrospective cohort from the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) of 4800 patients from 25 centers found that 6 targeted therapies (4 VEGF-TKIs and 2 mTOR inhibitors) were used in at least 9% of patients in the third-line setting [6]. The gene discussed is MTOR; the disease is renal cell carcinoma.