,43 Proposed cancer progression roles for MUC5AC in adenocarcinoma include overexpression of MUC5AC in intercellular junctions that interfere with the membrane localization of E-cadherin, compromise cell-cell adhesion, and increase migration and invasion of pancreatic ductal adenocarcinoma cells.39 The gene discussed is MUC5AC; the disease is pancreatic ductal adenocarcinoma.