As the SOCS family functions to act as negative regulators of cytokines [5], which can modulate immunological response of host to the Mtb infection [1,2,6,7], significant differences found in expressions of SOCS-2, -3, -4, -5, -6, -7, and CIS-1 genes among healthy, LTBI and active TB subjects may reflect the roles of the seven members of the SOCS family involved in immune regulation and cytokine signaling of human tuberculosis. The gene discussed is CISH; the disease is tuberculosis.