NF-κB has been studied extensively in inflammation and it is known to regulate pro-inflammatory cytokines such as IL-1β, IL-2, TNF-α and chemokines such as IL-8 and reports state that β-catenin interacted with NF-κB in human colon and breast cancer cells and it was found that β-catenin could physically complex with NF-κB, resulting in a reduction of NF-κB DNA binding, transactivation activity and target gene expression [20–23]. The gene discussed is NFKB1; the disease is breast cancer.