In agreement with our results, previous studies have reported that enhanced c-Myc and N-Myc expression makes neuroblastoma and B-cells addicted to glutamine [17, 21] and suppression of glutamine metabolism, by inhibition of IDH1, IDH2 or GLS expression reduces cellular proliferation and tumor growth [20, 29–31]. The gene discussed is IDH1; the disease is neuroblastoma.