Extensive studies have been conducted on P2XR and/or NLRP3 inflammasome in colon cancer [17], melanoma [19], prostate cancer [18], and lung cancer [15], but only a few studies has been done in the field of Head and Neck Squamous Cell Carcinoma (HNSCC). This evidence concerns the gene NLRP3 and head and neck squamous cell carcinoma.