Previous studies have reported that either immune or non-immune cells under certain pathologic conditions such as Sjögren's syndrome [10], Bechet's disease [11], Type 2 diabetes [12], rheumatoid arthritis [13], and various types of cancers [2, 4, 14–18] show elevated expression of P2XR and/or NLRP3 inflammasome. This evidence concerns the gene NLRP3 and cancer.