NLRP3 and cancer: The over-expression of P2X7R and NLRP3 inflammasome components in cancer tissues was further observed through using two types of salivary gland epithelial cell lines: Human Salivary Gland (HSG) cells derived from the duct of human submandibular glands and A253 cells derived from the epidermoid carcinoma harvested from human submandibular glands.