Protein levels cancer stem-like biomarkers (CD133, ALDH1, Lgr5, E-cadherin, Vimentin, Snail1) were also tested, indicating that the expression of CD133, ALDH1, Lgr5, Vimentin and Snail1 in the 131I-AC133.1 mAb group were lower than the other groups, while the level of E-cadherin was higher (Figure 4). This evidence concerns the gene LGR5 and cancer.