Moreover, the protein level of other stem-like markers were tested, the expression of Lgr5, ALDH1, Vimentin and Snail1 in 131I-AC133.1 mAb group were lower than other observed in the other groups, while the level of E-cadherin was higher, as the expression of E-cadherin is negatively correlated with tumor invasion and metastasis. The gene discussed is SNAI1; the disease is neoplasm.