AR and posterior cortical atrophy: ZEB1, a transcription factor whose expression has been reported greatly increased after chemical or physical castration in LuCaP35 normal prostate xenograft model, human prostate specimens and LNCaP cell line, by potentially functioning as AR transcriptional suppressor, intervenes in EMT induced by androgen deprivation through a bidirectional negative feedback loop with androgen receptor, revealing a potentially important consequence of a standard-of-care treatment for PCa [24].