Moreover, PON2 expression was investigated in urinary exfoliated cells obtained from a large cohort of BC patients, mainly with early stage neoplasms (pTa-1), and healthy donors, in order to explore the diagnostic/prognostic power of PON2 expression levels determination for early and non-invasive diagnosis of bladder cancer and for the prediction of the clinical outcome. The gene discussed is PON2; the disease is breast cancer.