AKR1C3 and breast cancer: In the strongly progesterone receptor (PgR) positive breast cancer cell line T-47D, progesterone, levonorgestrel, and medroxyprogesterone acetate were shown to up-regulate HSD17B1 and HSD17B5 expression and down-regulate HSD17B2 expression, with smaller effects seen on HSD17B1 expression in the moderately positive MCF7 [79].