In that study, the authors also noted a dose-response relationship between the amount of L-NAME ingested and the severity of hypertension as well as a positive relationship between NOS expression and norepinephrine turnover rate after treatment with L-NG-nitroarginine methyl ester, suggesting that endogenous NO inhibits sympathetic nervous activity in the brain and is involved in the neurogenic inhibitory regulation of blood pressure. The gene discussed is NOS1; the disease is hypertensive disorder.