In that study, the authors also noted a dose-response relationship between the amount of L-NAME ingested and the severity of hypertension as well as a positive relationship between NOS expression and norepinephrine turnover rate after treatment with L-NG-nitroarginine methyl ester, suggesting that endogenous NO inhibits sympathetic nervous activity in the brain and is involved in the neurogenic inhibitory regulation of blood pressure. Here, NOS1 is linked to Hypertension.