STAT3 and cancer: To detect the inhibitory effect of Raloxifene on persistent STAT3 phosphorylation, Hep-G2 (Figure 3A), 7721 (Figure 3B) and Huh-7 (Figure 3C) cancer cell-lines, which elevates the levels of STAT3 phosphorylation, were treated with Raloxifene (50, 75 μM) for 24 hours.