When stratified by cancer type, we found that in CRC no significant correlation was found between SATB1 expression and TNM stage (1296 patients; pooled OR: 1.59, 95% CI 0.93–2.71, p = 0.09), T stage (1431 patients; pooled OR: 1.48, 95% CI 0.86–2.55, p = 0.16), lymph node metastasis (1654 patients; pooled OR: 1.51, 95% CI 0.97–2.33, p = 0.07) and tumor differentiation (2147 patients; pooled OR: 1.16, 95% CI 0.69–1.97, p = 0.57). Here, SATB1 is linked to metastatic malignant neoplasm in the lymph nodes.