Univariate analysis of the validation cohort indicated that AFP, Child-Pugh score, PVTT, metastasis, BCLC, PLR, and SIRI were associated with OS, while gender, Hepatitis B Virus (HBV), cirrhosis, tumor size, local therapy, sorafenib treatment, NLR, and lymphocyte-monocyte ratio (LMR) had no prognostic significance for OS (Table 2). The gene discussed is AFP; the disease is neoplasm.