Though no obvious necrosis or apoptosis was found in the kidney of septic rats at 12 hours after CLP operation, the mRNA expressions of HO-1, KIM-1 and NGAL which were well-characterized markers of renal proximal tubule injury were obviously enhanced [23–25], while resveratrol substantially reversed these changes, suggesting that early administration of resveratrol was able to protect against sepsis-induced renal proximal tubule injury. The gene discussed is LCN2; the disease is Sepsis.