Therefore, we further assessed IER5 expression level among three subgroups of tumor diameter 4 cm, 4–5 cm and > 5 cm group, using the simple effect analysis show that as the tumor diameter of < 4 cm or of 4–5 cm before treatment, the expression of IER5 varied significantly with the radiation dose (p < 0.001 and p < 0.001), but the tumor diameter of > 5cm was not (Figure 2). The gene discussed is IER5; the disease is neoplasm.