The miRNA let-7, in addition to its other tumour suppressor roles, targets DNA-binding protein HMGA2 [61,62,63], which activates expression of Snail, Slug and Twist [64].A number of anti-EMT miRNAs are activated by p53 including miR-34a and miR-200 family members [65,66,67]. The gene discussed is SNAI2; the disease is neoplasm.