HOTAIR also silences miR-568 via recruitment of both EZH2 and LSD1 to the miR-568 promoter in breast cancer cells, leading to derepression of the miR-568 target NFAT5, which induces of EMT and invasion in breast cancer via transcriptional activation of calcium binding protein S100A4 [117]. Here, S100A4 is linked to breast carcinoma.