In one example, modulation of miR-326/SP1 pathway by HOTAIR was shown to reverse chemoresistance of lung adenocarcinoma cells [445], while in the development of cisplatin resistance in gastric cancer HOTAIR also uses a mechanism that activates the PI3K/AKT/MRP1 pathway via inhibition of miR-126 expression [446]. This evidence concerns the gene AKT1 and gastric cancer.