EZH2 and cancer: Epithelial cells generally express very low levels of EZH2, while increased levels are often observed in cancer where EZH2 promotes EMT, invasiveness and metastasis via silencing of the E-cadherin promoter by H3K27 trimethylation, with knockdown of EZH2 able to reverse both the H3K27 trimethylation of the E-cadherin promoter and EMT [85,86,87].