ZEB2 and Familial prostate cancer: The precise mechanism by which CCAT2 regulates EMT are currently unknown, but in gastric cancer CCAT2 interacts with EZH2 and promotes EMT by downregulation of E-cadherin expression and upregulation of ZEB2, LATS2, Vimentin and N-cadherin [224], and similar effects of CCAT2 expression on E-cadherin, N-cadherin and vimentin were observed in prostate cancer [323].