UCA1 activates Akt/mTOR signalling to promote EMT in EGFR-mutant NSCLC [194], whilst knockdown of lncRNA BC087858 in NSCLC inhibited the activation of the PI3K/Akt and MEK/ERK pathways and epithelial-mesenchymal transition (EMT) via up-regulating ZEB1 and Snail, and restored sensitivity to gefitinib in NSCLC which had acquired resistance to this targeting agent in the absence of T790M mutation of the EGFR [232]. This evidence concerns the gene ZEB1 and non-small cell lung carcinoma.