An increasing number of studies suggest that ADAM28 plays a crucial role in the pathogenesis of several diseases [18,19,20,21,22,23,24,25], particularly in cancers such as breast cancer [19], prostate cancer [21], B-cell acute lymphoblastic leukaemia [25], chronic lymphatic leukaemia [23], head and neck squamous cell carcinoma [24] and other conditions such as lethal acute respiratory infections [18]. The gene discussed is ADAM28; the disease is precursor B-cell acute lymphoblastic leukemia.