In acute pancreatitis, pro-inflammatory cytokines such as interleukin-1β, inerleukin-6, and tumor necrosis factor-α (TNF-α) are primary produced within the pancreas and subsequently within distant organs, developing systemic inflammatory response syndrome (SIRS) and multiple organ failure (MOF) in severe cases of this disease [22,23]. This evidence concerns the gene TNF and acute pancreatitis.