TIMP1 and metastatic melanoma: In Figure 3C, we found that the reduction of AKT rendered cells less able to resist to anoikis. As AKT is activated only in the metastatic melanoma 4C11+ cell line (Figure 3A) and this activation was shown to contribute to anoikis resistance (Figure 3C), we checked whether there would be a correlation between AKT and Timp1.