TIMP1 and cancer: Decreasing Timp1 expression in 4C11− and 4C11+ melanoma cells resulted in less effective anoikis resistance, colony formation, chemotherapy resistance, in vivo tumor growth, and metastatic colony formation in the lung (Figure 1 and Figure 2), showing that Timp1 confers advantages which are essential for melanoma development, as it was shown for some other cancers.