Amongst these coactivators, the YAP (Yes-associated protein) protein is often overexpressed in cancers, and targeting the YAP:TEAD interaction is emerging as a new therapeutic strategy in oncology (Gong and Yu, 2015; Felley-Bosco and Stahel, 2014; Santucci et al., 2015; Zhang et al., 2015). The gene discussed is YAP1; the disease is cancer.