SMPD3 and intracranial hemorrhage: Treatment with the nSMase2 inhibitor spiroepoxide (10 μM) or nSMase2 knockdown with MO led to severe intracranial hemorrhage accompanied with decreased expression of miR-132 in ECs of zebrafish larvae (Figure 5B, 5C and Supplementary information, Figure S8D-S8F; P < 0.05).