Furthermore, EC-specific overexpression of Eef2k (“Flk1:tdT-P2A-Eef2k”) also caused intracranial hemorrhage (Figure 6K; P < 0.01), DAPI leakage (Figure 6L and Supplementary information, Figure S10D; P < 0.001), and reduction of Cdh5 expression (Figure 6M; P < 0.01). The gene discussed is CDH5; the disease is intracranial hemorrhage.