HLA-G and primary systemic amyloidosis: β2-microglobulin (β2m) causes a iatrogenic form of systemic amyloidosis when associated to long term haemodialysis1 and is associated with a familial form of the disease in the presence of the D76N mutation, characterized by progressive bowel disfunction and extensive amyloid deposits in the spleen, liver, heart, salivary glands and nerves2.