PLAU and asthma: Notably, anticoagulant therapy is not used in asthma treatment nowadays, although interventions with anticoagulants such as fondaparinux (FXa inhibitor) and hirudin (thrombin inhibitor), as well as the use of tPA and uPA improved the disturbed pulmonary hemostatic balance and concurrently diminished airway inflammation and improved asthma parameters, including features of airway remodeling, in experimental settings [3].