Activation of these receptors by thrombin, FXa, and TF/FVIIa leads to the overproduction of, e.g., IL-6, IL-8, platelet-derived growth factor, and P-selectin and also might participate in airway remodeling, another important feature of asthma, which develops independently of corticosteroid therapy and severity of bronchial inflammation [36, 37]. Here, CXCL8 is linked to asthma.