Furthermore, de novo MLL-ENL translocations caused myeloproliferative-like myeloid leukaemia development in all mice in which Cre recombinase was expressed from Lmo2, Lck and Rag1 genes (expressed in non-differentiated cells, T-cell linage and early staged of lymphoid lineage, respectively); while no haematological malignancies were observed in MLL-ENL Cd19-Cre (gene expressed in B cell lineage) [87]. The gene discussed is KMT2A; the disease is myeloid leukemia.