The authors therefore suggested that granulocyte-monocyte-lymphoid progenitors (GMLPs), as a subpopulation of the wider Lineage−Sca-1+c-kit+ (LSK) population [91], and GMP precursors (pGMs) represent the most permissive cellular environment for regulatory program perturbations that can cause leukaemia development. This evidence concerns the gene KIT and leukemia.