Nevertheless, a recent study published in 2016 [92] using another MLL-AF9 Dox inducible mouse model (67), showed that both long-term HSCs (LT-HSCs) and GMP were transformed by MLL-AF9 induction, where transformation in LT-HSCs resulted in a more aggressive AML phenotype. This evidence concerns the gene MLLT3 and acute myeloid leukemia.