Jamieson et al., showed that non self-renewing cells were transformed into LSC in human blast crisis chronic myeloid leukaemia (CML), where activation of the Wnt/β-catenin pathway enhanced self-renewal ability of BCR-ABL expressing granulocyte-macrophage progenitors [53]. This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.