Besides, it was reported that INSR gene expression was downregulated in miR-135a-5p transfected C2C12 cells [102]. IRS1 and/or IRS2 mRNAs were correlated with (1) let-7f-5p in T2DM mice [100]; (2) miR-15b-5p in T2DM humans [101]; (3) miR-29a-3p in IR-obese mice [103]; (4) miR-135a-5p in T2DM mice [104]; and (5) miR-144-3p in T2DM rats [105]. This evidence concerns the gene IRS2 and type 2 diabetes mellitus.