In T2DM humans, reduced activation of early steps of insulin signaling, such as IRS1/PI3K [24, 28], and downstream steps such as activation AKT, PKC-zeta, and TBC1D4 [28, 65, 66] have been observed to be impaired, thus compromising insulin-stimulated GSV translocation. This evidence concerns the gene IRS1 and type 2 diabetes mellitus.