AKT2 and type 2 diabetes mellitus: PI3KR1 mRNA was proposed to be regulated only by miR-15b-5p in T2DM humans [101]. AKT2 mRNA reduction was correlated to reduced expression of miR-23a and miR-107 after loss of weight in obese dogs [106], suggesting an unexpected and incomprehensible increasing of AKT2 in the obese insulin resistant dogs before the weight loss.