Additionally, Moon et al. demonstrated that the mortality rate of wild-type rats with cecal ligation and puncture- (CLP-) induced sepsis was higher than that of UCP2-knockout rats and that UCP2 may increase the expression of fatty acid synthase (FASN) and promote NLRP3 inflammasome activation during sepsis [19]. The gene discussed is NLRP3; the disease is Sepsis.