The purpose of this study was to evaluate the association between CNVs in specific regions of LEPR, NEGR1, ARHGEF4, CPXCR1, and INS and in four intergenic regions (1p36.33b, 12q15c, 15q21.1a, and 22q11.21d) and obesity in Mexican children. The gene discussed is ARHGEF4; the disease is Obesity.