PRNP and colon adenocarcinoma: PrPC has also been observed to promote proliferation of colon adenocarcinoma cells (Chieng and Say, 2015), neuroblastoma cells (Llorens et al., 2013), cancer stem cells that give rise to glioblastoma (Corsaro et al., 2016), and precursor cells in intestinal organoid cultures (Besnier et al., 2015).