KIT and leukemia: Additionally, the possibility that tetraspanins, such as CD63, might stabilize c-Kit and modulate signaling through alterations in protein trafficking could have significant impact on specific leukemias where c-Kit expression and activation are known to be dysregulated (Ikeda et al., 1991; Goemans et al., 2005; Boissel et al., 2006; Corbacioglu et al., 2006; Paschka et al., 2006).