TNF and Multiple Organ Failure: Sepsis in general can result in multiple organ failure and death as a consequence of uncontrolled activation of the innate immune system with high circulating levels of pro-inflammatory cytokines such as interleukin 6 (IL-6), IL-8, IL-1β and tumor necrosis factor α (TNFα) (Nupponen et al., 2001; Santana et al., 2015).