Also in this type of analyses, the homogeneous distribution in both tumor regions (i.e., combined CD8+/CD163+ high and/or low cell densities in both TC and IM; HH/HH, LL/LL, HH/LL and LL/HH), could not significantly discriminate for DFS or OS (Fig. 4e, f). This evidence concerns the gene CD8A and neoplasm.