Similar to published data using cell line tumor models, treatment of the mammary intraepithelial neoplasia-outgrowth (MIN-O) model [9], a tissue transplant line, with anti-CD40 and IL-2 immunotherapy (IT) led to significant anti-tumor responses (P = 0.0057) including regression in >50% of the treated mice (Additional file 1: Figure S1A). The gene discussed is IL2; the disease is neoplasm.